Description

Description

Description

Niacinamide 500 from Progressive Laboratories provides 500 mg of vitamin B3 as niacinamide per vegetable capsule. Niacinamide (vitamin B3) is a precursor of nicotinamide adeninedinucleotide (NAD), essential for oxidation-reduction reactions, nutrient metabolism and ATP synthesis. It does not cause the flush commonly associated with niacin that many find unpleasant.

Niacin and niacinamide are required for the proper function of fats and sugars in the body and to maintain healthy cells. At high doses, niacin and niacinamide can have different effects. Niacin might help people with heart disease because of its beneficial effects on clotting. It may also improve levels of a certain type of fat called triglycerides in the blood. Niacinamide has no beneficial effects on fats and should not be used for treating high cholesterol or high fat levels in the blood.

Niacin deficiency can cause a condition called pellagra, which causes skin irritation, diarrhea, and dementia.

Research indicates that niacinamide may support healthy glucose metabolism and protect pancreatic cell function. In another study, niacinamide helped maintain healthy C-peptide levels and glucose metabolism. Niacinamide also promotes joint mobility and comfort. In a 12-week randomized double-blind trial involving 72 subjects, niacinamide provided statistically significant support for joint flexibility and normal inflammatory response.

People with poor diet, alcoholism, and some types of slow-growing tumors called carcinoid tumors might be at risk for niacin deficiency.

Warning: If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.

Ingredients

Dosage

One vegetable capsule twice daily with meals.

Count

60 Vegetable Capsules

Science

Zeman M, Vecka M, Perlk F, Hromdka R, Stakov B, Tvrzick E, k A. Niacin in the Treatment of Hyperlipidemias in Light of New Clinical Trials: Has Niacin Lost its Place? Med Sci Monit. 2015 Jul 25;21:2156-62. doi: 10.12659/MSM.893619. PMID: 26210594; PMCID: PMC4523006.

Blankenhorn DH, Nessim SA, Johnson RL, Sanmarco ME, Azen SP, Cashin-Hemphill L. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA. 1987 Jun 19;257(23):3233-40. Erratum in: JAMA 1988 May 13;259(18):2698. PMID: 3295315.

Lavigne PM, Karas RH. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J Am Coll Cardiol. 2013 Jan 29;61(4):440-446. doi: 10.1016/j.jacc.2012.10.030. Epub 2012 Dec 19. PMID: 23265337.

AIM-HIGH Investigators. The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: impact on Global Health outcomes (AIM-HIGH) trial. Am Heart J. 2011 Mar;161(3):538-43. doi: 10.1016/j.ahj.2010.12.007. Epub 2011 Feb 2. PMID: 21392609; PMCID: PMC3120223

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